Review Published: 2018 International Journal of Molecular Sciences Cartilage Regeneration in Humans with Adipose Tissue-Derived Stem Cells and Adipose Stromal Vascular Fraction Cells: Updated Status
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Jaewoo Pak 1,†, Jung Hun Lee2,† ,Natalie Pak 1, Yoon Pak 3, Kwang Seung Park 2, Jeong Ho Jeon 2, Byeong Chul Jeong 2 and Sang Hee Lee 2
1 Mipro Medical Clinic, 32-3 Chungdamdong, Gangnamgu, Seoul 06068, Korea
2 National Leading Research Laboratory, Department of Biological Sciences, Myongji University, 116 Myongjiro, Yongin, Gyeonggido 17058, Korea
3First Medical Center, 11841 South St., Cerritos, CA 90703, USA
†These two authors contributed equally to this work.
Adipose tissue-derived stem cells (ASCs) in the form of stromal vascular fraction (SVF) and cultured expansion have been applied in clinical settings in some countries to treat osteoarthritis (OA) of knees, one of the most common debilitating, incurable disorders. Since the first report of successful cartilage-like tissue regeneration with autologous adipose SVF containing ASCs, there has been a gradual increase in the number of publications confirming such results. Thus far, most of the reports have been limited to treatments of OA of knees. Recently, successful applications of adipose SVF in treating OA of ankles and hips have been reported. In addition, several groups have reported modified methods of applying adipose SVF, such as combining bone marrow stimulation with adipose SVF or adding additional extracellular matrix (ECM) in treating OA. Here, we present an updated, systematic review of clinical effectiveness and safety in treating OA of knees, ankles, and one hip since 2016 using ASCs in the form of adipose SVF or in cultured expansion, along with a description and suggestion of potential biological mechanisms of cartilage regeneration.
Keywords: adipose tissue-derived stem cells; stromal vascular fraction; human cartilage regeneration; osteoarthritis