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Article Published:  2015 October

Journal of Plastic, Reconstructive & Aesthetic Surgery (2015)

Stromal vascular fraction: A regenerative

Part 1: Current concepts and review
of the literature

 Andrew Nguyen, James Guo,  et al

Adipose tissue is a rich source of cells with emerging promise for tissue engineering
and regenerative medicine. The stromal vascular fraction (SVF), in particular, is an eclectic
composite of cells with progenitor activity that includes preadipocytes, mesenchymal stem
cells, pericytes, endothelial cells, and macrophages. SVF has enormous potential for therapeutic
application and is being investigated for multiple clinical indications including lipotransfer,
diabetes-related complications, nerve regeneration, burn wounds and numerous others. In
Part 2 of our review, we explore the basic science behind the regenerative success of the
SVF and discuss significant mechanisms that are at play. The existing literature suggests that
angiogenesis, immunomodulation, differentiation, and extracellular matrix secretion are the
main avenues through which regeneration and healing is achieved by the stromal vascular fraction.

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