Article Published: 2016 Jul 29
Orthopaedic Journal pf Sports Medicine
Treatment of Achilles Tendinopathy with Autologous Adipose-derived Stromal Vascular Fraction Results of a Randomized Prospective Clinical Trial
Achilles tendinopathy commonly occurs in both active and inactive persons. It consists in the development of pain and inflammation in the early phases, with progression to the development of fibrotic tissue and degeneration of tendon matrix. Current treatment approaches do not provide sustained satisfactory results, particularly in active patients. Platelet rich plasma (PRP) injection have however been shown to be effective in many cases. The therapeutic effect of adipose-derived mesenchymal stem cells (ASCs), either expanded or used directly within the stromal vascular fraction (SVF), have demonstrated to possess significant anti-inflammatory and immunomodulatory effects. These are also mediated by the release of active factors, and thus potentially useful in the treatment of tendinopathy.
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