Article Published:  2016 Jul 29

Orthopaedic Journal pf Sports Medicine

Treatment of Achilles Tendinopathy with Autologous Adipose-derived Stromal Vascular Fraction Results of a Randomized Prospective Clinical Trial

Laura de Girolamo, PhD, Miriam Grassi, Marco Viganò, Carlotta Perucca Orfei, Umberto Alfieri Montrasio, and Federico Usuelli, MD

Abstract
Achilles tendinopathy commonly occurs in both active and inactive persons. It consists in the development of pain and inflammation in the early phases, with progression to the development of fibrotic tissue and degeneration of tendon matrix. Current  treatment approaches do not provide sustained satisfactory results, particularly in active patients. Platelet rich plasma (PRP) injection have however been shown to be effective in many cases. The therapeutic effect of adipose-derived mesenchymal stem cells (ASCs), either expanded or used directly within the stromal vascular fraction (SVF), have demonstrated to possess significant anti-inflammatory and immunomodulatory effects. These are also mediated by the release of active factors, and thus potentially useful in the treatment of tendinopathy.

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